Applications of bacterial transformation are : 1) to make multiple copies of DNA called DNA cloning. 2) to make large amounts of specific human proteins, for example human insulin, which can be used to treat people with Type I diabetes. 3) to genetically modify a bacterium or ather cell.
Transformation is the process by which foreign DNA is introduced into a cell. Transformation of bacteria with plasmids is important not only for studies in bacteria but also because bacteria are used as the means for both storing and replicating plasmids.
Transformation, in biology, one of several processes by which genetic material in the form of “naked” deoxyribonucleic acid (DNA) is transferred between microbial cells. Its discovery and elucidation constitutes one of the significant cornerstones of molecular genetics.
History of Bacterial Transformation and Plasmids Bacterial Transformation was discovered in 1928 by a British medical officer, Frederick Griffith. During a test regarding pneumonia, he discovered that a strain of pneumonia could transform into a virulent strain.
Bacterial transformation is a widely used method where foreign DNA is introduced into a bacterium, which can then amplify, or clone the DNA. Cells that have the ability to readily take up this DNA are called competent cells.
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