In non-obese adults with normal kidney function, they recommend a loading dose of 20-35mg/kg/day, with a maximum dose of 3000mg given in a single dose. For non-obese children and neonates, a loading dose is not recommended. If the adult patient is obese, loading doses of 20-25mg/kg using actual body weight, up to 3000mg may be considered.
Black, tarry stools bleeding gums blood in the urine or stools continuing ringing or buzzing or other unexplained noise in the ears cough or hoarseness dizziness or lightheadedness feeling of constant movement of self or surroundings feeling of fullness in the ears fever with or without chills general feeling of tiredness or weakness More items...
Toxic: Peak vancomycin concentrations >80−100 μg/mL may be associated with ototoxicity. For patients on concomitant or sequential therapy with other oto- and/or nephrotoxic agents, vancomycin concentrations >30 μg/mL may be associated with nephrotoxicity.
vancomycin trough concentration should be drawn with morning labs pre-dialysis on Wednesday. If the level is 15-20 mcg/mL, then the patient should receive 750 mg of vancomycin after that dialysis, and with each subsequent dialysis session. The vancomycin levels would be drawn weekly.
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